Effect of carbachol injection in the medial preoptic area on sleep-wakefulness and body temperature in free moving rats.
نویسندگان
چکیده
The aim of the present study was to find out the changes in sleep-wakefulness and body temperature brought about by application of cholinergic agonist, carbachol, in the medial preoptic area (mPOA). Carbachol, when injected bilaterally into the mPOA of male rats, through chronically implanted cannulae, produced a fall in rectal temperature and long lasting arousal. There was temporal dissociation in the duration of changes produced in the two parameters. It is suggested that the cholinergic system at the medial preoptic area brings about arousal response and fall in body temperature through different circuits.
منابع مشابه
Changes in Body Temperature and Sleep-Wakefulness After Intrapreoptic Injection of Methoxamine in Rats
Several pieces of evidence suggest that the noradrenergic afferents in the medial preoptic area produce sleep and hypothermia by acting on alphal adrenergic receptors. On the other hand, in a few studies monitoring body temperature with a rectal probe, preoptic injection of the alphal adrenergic agonist methoxamine produced contradictory changes in body temperature and sleep-wakefulness. Such c...
متن کاملEffect of ambient temperature on brain temperature and sleep-wakefulness in medial preoptic area lesioned rats.
The changes in brain temperature and sleep-wakefulness were studied in rats during their exposure to different ambient temperatures of 18 degrees C, 24 degrees C and 30 degrees C, before and after N-methyl D-aspartic acid lesion of the medial preoptic area. The medial preoptic area lesion produced a decrease in sleep, and increase in brain temperature except at 30 degrees C. Increase and decrea...
متن کاملEffect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness.
Intracerebral microinjections of gamma amino butyric acid were given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotransmitter in the genesis and regulation of sleep-wakefulness. GABA (50 micrograms/0.2 microliters) when administered through chronically implanted cannulae in free moving rats, did not produce any significant alterations in sleep-wakef...
متن کاملThe medial septum acts through the medial preoptic area for thermoregulation and works with it for sleep regulation.
The chronic changes in sleep-wakefulness (S-W), body temperature (Tb), locomotor activity (LMA) and thermal preference were studied in male Wistar rats after the destruction of neurons in both the medial preoptic area (mPOA) and the medial septum (MS) by intracerebral injection of N-methyl-D-aspartic acid. An increase in the Tb, and a preference for higher ambient temperature (Tamb) of 30 degre...
متن کاملWhy the medial preoptic area is important for sleep regulation.
The medial preoptic area (mPOA) is one of the many areas in the brain that control sleep. Apart from sleep, the mPOA is important for the regulation of body temperature, and other important body functions aimed at energy homeostasis. In sleep regulation, the major function of this area is to maintain sleep. Though the mPOA controls sleep and body temperature through independent neuronal circuit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 38 3 شماره
صفحات -
تاریخ انتشار 1994